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Sze Wing Wong Degree:
Ph.D., Chemical
Engineering
Advisor:
Christos Georgakis
Research Project: On-line Estimation
of PSD in Polymorphic Crystallization
Project Description:
The area of optimization and control of
crystallization process is one of the most
important research themes in the
pharmaceutical industry. Not only because
crystallization is the major industrial
process used in separation and purification,
but also due the lack of understanding and
control of the polymorphic crystallization
resulting in product failures. This issue is
particularly important in the pharmaceutical
industry because the bioactivity and
stability changes significantly with the
different polymorphic forms of a drug.
Therefore it is critical to identify all the
possible forms of the active compound and
investigate the stability and bioactivity of
each form because there is strict FDA (Food
& Drug Administration) regulation in
assuring the purity of the product.
The aim of this project is to investigate
how to convert Chord Length Distribution (CLD)
to PSD and to obtain the polymorphic
composition in real time. The proposed
analytical method will use several in-line
analytical tools. Experiments will be
conducted in batch crystallizer equipped
with the analytic measurement capabilities
which consists of: (1) Raman Spectroscopy;
(2) Focused Beam Reflectance Measurement (FBRM);
(3) Process Video Measurement (PVM); (4)
Attenuated Total Reflection Fourier
Transform Infrared (ATR FTIR); and (5)
Temperature and agitation controlled batch
crystallizer.
Education & Experience:
B.S. (cum laude) in Chemical Engineering,
2003
Polytechnic University
Funding:
Tufts University
Publications & Presentations:
Article in Press:
Factors affecting on-line estimation
of diastereomer composition using Raman
spectroscopy. Control Engineering
Practice (2007).
S. Wong, C. Georgakis, G.
Botsaris, K. Saranteas, and R. Bakale.
(2006).
Factors Affecting On-line Estimation of
Diastereomer Composition using Raman
Spectroscopy. ADCHEM Proceedings.
S. Wong, C.
Georgakis and G. Botsaris (2006). On-line
Estimation of Diastereomer Composition using
Raman: Differentiation in High and Low
Slurry Density PLS Models.
AIChE Annual Meeting.
S. Wong, C.
Georgakis and G. Botsaris (2006). On-line
Estimation of Diastereomeric Resolution with
FBRM, Raman Spectroscopy and ATR-FTIR.
AIChE Annual Meeting.
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